View clinical trials related to Hyperkinesis.
Filter by:The purpose of this research is to learn more about how children with mental health problems, including bipolar disorder (BD), attention deficit hyperactivity disorder (ADHD), and generalized anxiety disorder (GAD), differ from children without these problems. The investigators want to understand how these 4 groups of children differ in brain activity, function, and structure.
Heavy metal has been reported that it can cause attention deficit and behavioral disturbance. The investigators hypothesis is that heavy metal is associated with children with attention deficit/hyperactivity disorder(ADHD).
The study hypothesis is that some children with Attention-Deficit-Hyperactivity-Disorder (ADHD) who also have sleep onset difficulties will improve with Melatonin treatment to an extent similar to that of stimulants treatment. In order to check this hypothesis children with a new ADHD diagnosis who also have sleep difficulties will be treated with either Melatonin or with stimulants (Methylphenidate) for one month. The main outcome will be improvement of the ADHD symptoms.
This proposal seeks to obtain preliminary data on the potential efficacy, tolerability, and feasibility of trigeminal nerve stimulation (TNS) as a treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). If successful, this open-label, exploratory, pilot study will provide a basis for a federal grant application and larger controlled trials.
Attention deficit hyperactivity disorder (ADHD) is the most common behavior disorder, with the prevalence of 3% to 6% in children and adolescents. The patients' academic achievements, professions and social livings are impaired. Comorbid antisocial behavior, substance abuse and delinquency burden family and society. Stimulants used to be the first line drug. But the medication compliance is poor because of strict drug administration. Atomoxetine is a new non-stimulant drug, which can effectively improve ADHD symptoms. But it achieves effect slowly, the drug responses differ significantly, and side effects interfere compliance. Since genetic factors is the most important cause for different drug responses, this project studies candidate genes potentially associated with atomoxetine medication, with the aim to find 2 to 3 gene polymorphisms influencing the drug response of ADHD. The study adopts cohort design. A sample of more than 100 ADHD cases with atomoxetine medication is to be collected. The rapid genotyping of large sample depends on high-through laboratory. New statistic method is to be used to improve the sensitivity of the target gene detection. There has been no such report in country and overseas. This project will provide basic information for forecasting drug response, improving clinical effects, tolerance and long-term compliance.
The purpose of this study is to examine the efficacy of the ADHD-Toolkit (a toolkit for school behaviour modification in primary school children with ADHD-behaviours) in terms of general improvement in ADHD symptoms, specific targeted school-related problem behaviours, other disruptive behaviour disorder symptoms, teacher attitudes towards ADHD, teacher-child relationship and child self-esteem.
Type of study: This study is a prospective, randomized, placebo controlled, double blind trial comparing the response to treatment in children with a diagnosis of ADHD treated with stimulants and placebo vs. children with a diagnosis of ADHD on stimulants plus Omega-3 fatty acids. Hypothesis: The use of Lovaza (prescription Omega-3 fatty acids) as an adjunctive therapy for children with adequate diagnosis of ADHD on treatment with stimulants will not improve their functioning and behavior measured by the Parent and Teacher Conner's Rating Scale and an improvement in their Clinical Global Impression. Method: A total of 30-150 patients between ages of 6 and 15 y/o with diagnosis of ADHD according to the DSM-IV-TR and on current treatment with stimulants recruited from CAOS-Maimonides Medical Center and the Developmental Center will be evaluated by a child psychiatrist or a resident under supervision of a child psychiatrist to make sure that the diagnosis is correct. Every child will have a Conners Rating Scale filled out by the parents and teachers on admission to the study. The evaluators will also fill out a Clinical Global Impression Scale (CGI). Patients will be divided in two groups, one will consist of 15 children taking usual dose of stimulants plus placebo and the other group, 15 children will receive the usual dose of stimulant plus Lovaza at a dose of 1800mg daily. Both groups will be treated for 8 weeks. Patients will be re-evaluated by investigators on week 2,4,6 and 8 of the study and on each evaluation the parents and teachers will fill out a Conner's rating scale. Ratings of the Conner's scales filled out for each patient will be analyzed and compared to the initial evaluation after week 8. Evaluators will also obtain a CGI score for each visit. Patients that improve will be taken off the stimulants and will continue further treatment with the adjunctive therapy for a total of 4 more weeks, during this period of time, they will be re-evaluated on weeks 9,10 and 12 and Conner's Scales will also be filled out by parents. Patients who do not improve will be switched to the opposite treatment modality and will be evaluated on weeks 9,10 and 12 also having Conner's Scales filled out by their parents. If any of the patients in this group improve (after the switch) they will be taken off stimulants and they will be evaluated on weeks 13,14 and 16 of the study arm. The idea is to conduct the study and obtain information about prescription Omega-3 fatty acids as an adjunct to stimulants for patients with ADHD, as several publications have been done in the past suggesting it can be beneficial, but there have not been any conclusions on whether the treatment is beneficial or not for this population.
The aim of the study is to assess the effect of left or right high-frequency DTMS on ADHD symptoms, cognitive performance and decision-making ability of ADHD adults, and to compare this to the effect of sham DTMS on ADHD adults
There is little accurate data in the literature at present on oral problems of hyperactive children, especially regarding care needs that would justify an assumption oral specific. The purpose of this study is therefore to have accurate data regarding the risk of caries, other oral diseases like periodontal disease, trauma, and assess the needs dental care and problems in cooperation for dental care in a population of children and adolescents with hyperactivity disorder with attention deficit. Finally, it has recently been described as the sleep disordered breathing was not uncommon in disorder attention deficit/hyperactivity disorder, whether snoring and/or apnea. But it is now accepted that some features of facial morphology favoring pharyngeal congestion occur in individuals with obstructive sleep apnea (hyperdivergent typology with increased anterior facial height and decreased posterior facial height, becoming the facial retrognathia, pharyngeal congestion, elongation and thickening of the soft palate, low position of the hyoid bone). A cephalometric analysis of craniofacial architecture and relationships with the soft tissue surrounding skeletal structures will detect if any of these specific characteristics that could promote sleep disordered breathing are found in disorder attention deficit/hyperactivity disorder prevalence with a particular.
The purpose of this study is to detect specific vocal acoustic patterns in the voice of attention deficit hyperactivity disorder (ADHD) patients.