Hyperemesis Gravidarum Clinical Trial
Official title:
Is Hyperemesis Gravidarum a Risk Factor for Osteoporosis ?
Verified date | April 2017 |
Source | Adana Numune Training and Research Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Hyperemesis Gravidarum (HG) is a common disorder for hospitalization in the first trimester of pregnancy and related to protracted vomiting and nausea. It can be accompanied by ketonuria, dehydration and weight loss. Our aim was to investigate osteoporosis in patients with HG. In our study, we investigated osteoporosis in a total of 79 patients (40 HG and 39 control) by means of dual energy x-ray absorptiometry (DEXA) measurements and laboratory parameters related to HG.
Status | Completed |
Enrollment | 79 |
Est. completion date | December 15, 2015 |
Est. primary completion date | December 15, 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - diagnosed with hyperemesis gravidarum - treated with intravenous fluids in first trimester - primigravid singleton pregnant patients Exclusion Criteria: - Patients with diagnostic confounders such as overt hyperthyroidism, stomach disease, cholelithiasis, or gastroenteritis - Patients with chronic illness (e.g.Crohn's disease, colitis ulcerosa, chronic liver disease, diabetes, thyroid disfunction, hyperparathyroidism) and multigenerational pregnancies, - Patients with history of thyroid surgery, calcium and/or hormone producing tumours, systemic lupus erythematodes, - Patients with eating disorders, - Patients with usage of steroids, antiepileptic drugs and/or low molecular weight heparin (long term medication known to affect bone metabolism) and also patients with history of steroid usage for fetal lung maturation. - Patients with history of osteoporosis, bone fracture in young ages in family. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Adana Numune Training and Research Hospital |
Type | Measure | Description | Time frame | Safety issue |
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Primary | dual energy x-ray absorptiometry (DEXA) | All patients were performed on a standard dual energy x-ray absorptiometry (DEXA, Hologic Discovery Wi S/N 80848) during early postpartum period ( frequently in two days after birth before discharge of patients) by a single technician to assess osteoporosis. Blood samples include laboratory parameters associated with osteoporosis (Vitamin D, ALP, P, Ca and PTH). | up to 5 minutes | |
Secondary | blood tests | Blood samples (10 mL) were drawn at the time of DEXA scans in postpartum period and collected into ethylenediaminetetraacetate (EDTA) containing sterile tubes and serum separator tubes (SSTs) to assess osteoporosis. Blood samples include laboratory parameters associated with osteoporosis (Vitamin D, ALP, P, Ca and PTH). | up to 5 minutes |
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