The Effect of Viscous Dietary Fibers on LDL-cholesterol

Status Active, not recruiting

Clinical Trial Summary

This systematic review and meta-analysis is aimed to assess the effect of commonly consumed viscous fibers on blood lipids including LDL-C, non-HDL-C, and ApoB.

Clinical Trial Description

Medline, Embase, CINAHL, and the Cochrane Central databases were searched through May 13, 2019. Three independent reviews extracted data and assessed risk of bias. Randomized controlled trials that assessed the effect of barley b-glucan, oat b-glucan, konjac glucomannan (KJM), psyllium, guar gum, and pectin, with a study duration of ≥ 3 weeks, in adults with or without hypercholesterolemia were included. Data were pooled using the generic inverse variance method with random effects models and expressed as mean differences with 95% confidence intervals. Heterogeneity was assessed by the Cochran Q statistic and quantified by I2 statistic. Overall quality of the evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04133805
Study type	Observational
Source	St. Michael's Hospital, Toronto
Contact
Status	Active, not recruiting
Phase
Start date	September 17, 2018
Completion date	January 2020

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