Hypercapnic Respiratory Failure Clinical Trial
Official title:
Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure
Current evidence suggests a mechanistic and physiological rationale for the use of high flow nasal cannula (HFNC) in acute respiratory hypoxemic failure (AHRF) based on physiological studies in airway models, healthy volunteers and patients with Chronic Obstructive Respiratory Disease (COPD). This is supported by observational studies in patients with AHRF with reductions in a range of respiratory and other physiological parameters. Observational studies also suggest similar intubation rates and lower failure rates with HFNC when compared to non-invasive ventilation (NIV) with improved patient acceptance and tolerance for HFNC. The role of HFNC is less clear in acute hypercapnic respiratory failure. Although non-invasive ventilation is the recommended treatment, it is associated with discomfort, and a significant proportion (up to 25% in some reports) cannot tolerate non-invasive ventilation. Observational reports and limited data from randomized controlled trials suggests that HFNC is effective in treating patients with hypercapnic respiratory failure. We designed this trial to assess whether early application of HFNC in patients with non-severe hypercapnic respiratory failure can correct barometric abnormalities, and prevent progression to non-invasive ventilation or tracheal intubation and mechanical ventilation.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02845076 -
Weaning From Noninvasive Ventilation
|
N/A | |
Recruiting |
NCT05008211 -
Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients
|
N/A | |
Recruiting |
NCT03238339 -
The Clinical Application and Popularization of Portable Home Noninvasive Ventilator
|
||
Recruiting |
NCT06047405 -
NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
|
N/A | |
Completed |
NCT04108819 -
Ketogenic Diet for Obesity Hypoventilation Syndrome
|
N/A | |
Recruiting |
NCT02874339 -
High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema
|
N/A | |
Completed |
NCT01987661 -
The Effects of Airtrapping on Sleep and Breathing in Non Invasive Ventilation (NIV) in COPD
|
N/A | |
Completed |
NCT03398239 -
Comparison of BPAP ST/T and BPAP ST / T Mode With AVAPS for Hypercapnic Respiratory Failure in ED
|
N/A | |
Terminated |
NCT03353064 -
Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure
|
N/A | |
Completed |
NCT04072848 -
Mathematically Arterialised Testing of Hypercapnic Subjects Study
|
||
Not yet recruiting |
NCT04131660 -
Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation
|
N/A | |
Completed |
NCT02699112 -
Cardiac and Respiratory Function With Non-invasive Ventilation
|
||
Completed |
NCT01523470 -
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure
|
Phase 3 | |
Active, not recruiting |
NCT04709562 -
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
|
N/A | |
Not yet recruiting |
NCT06064409 -
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
|
||
Recruiting |
NCT04351906 -
Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome
|
N/A | |
Not yet recruiting |
NCT06367686 -
Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
|
||
Completed |
NCT03406572 -
Use of Nasal High Flow Oxygen During Breaks of Non-invasive Ventilation for Patients With Hypercapnic Respiratory Failure
|
N/A | |
Active, not recruiting |
NCT03364946 -
High Flow Therapy in ICUs Across Ibero America
|
||
Not yet recruiting |
NCT06257667 -
Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients
|
N/A |