Hypercapnic Respiratory Failure Clinical Trial
Official title:
High Flow Nasal Oxygen Versus VNI for Emergency Department Treatment of Acute Hypercapnic Cardiogenic Pulmonary Edema With Respiratory Failure: a Multicenter Randomized Non Inferiority Trial
The purpose of this study is to determine whether high flow nasal oxygen (HFNO) therapy is non inferior to non invasive ventilation (NIV) in the immediate treatment of patients with acute hypercapnic cardiogenic pulmonary edema associated with respiratory failure in the emergency department.
Prospective multicenter study including ED patients with a suspected diagnosis of acute
hypercapnic pulmonary edema with respiratory failure who require NIV according to the joint
recommendations from the French society of anaesthesia and intensive care and the French
society for intensive care.
Patients will be randomly assigned to NIV or high flow nasal oxygen therapy, with
stratification on center and severity of hypercania.
Assigned Treatment will be administered during at least one session of 1hr and resumed as
needed based on the patient's signs of respiratory distress and blood gas results Repeat
evaluation of arterial blood gases, clinical parameters and dyspnea will be performed before
and after the first and second hour of treatment according to current recommendation from the
French society of anesthesia and intensive care medicine (SFAR).
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