Hypercapnic Respiratory Failure Clinical Trial
Official title:
Dokuz Eylul University School of Medicine
The aim of the present study; To compare the effects of respiratory support options available for NIMV at the emergency department; i.e. AVAPS and ST/T modes, on the patient's pCO2 values, additional treatment need (another non-invasive ventilation method or endotracheal intubation) and the duration of stay in hospital.
Non-invasive positive pressure ventilation (NIMV) is a life-saving procedure for patients
with hypoxic and/or hypercapnic respiratory failure. AVAPS (average volume assured pressure
support) is a noninvasive ventilation mode which has been developed to assure volume and
pressure controlled respiratory support. AVAPS can ensure a constant tidal air volume to the
patient with variable pressure support. Thus the positive features of the volume and pressure
controlled support, which have a positive impact on the healing and recovery processes are
combined.
This study aims to compare, in a randomized order, BPAP ST/T and BPAP ST / T Mode with AVAPS,
in patients with hypercapnic respiratory failure in the emergency department.
Subjects: One hundred and two patients with hypercapnic respiratory failure will be included.
Primary outcome; decrease in the PaCO2 values
Secondary outcomes are stated as; Failure of treatment options, or change of the NIMV mode
due to patient noncompliance or the patient's need for intubation and length of hospital stay
(length of stay in the hospital from the emergency department).
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02845076 -
Weaning From Noninvasive Ventilation
|
N/A | |
| Recruiting |
NCT05008211 -
Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients
|
N/A | |
| Recruiting |
NCT03238339 -
The Clinical Application and Popularization of Portable Home Noninvasive Ventilator
|
||
| Recruiting |
NCT06047405 -
NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
|
N/A | |
| Completed |
NCT04108819 -
Ketogenic Diet for Obesity Hypoventilation Syndrome
|
N/A | |
| Recruiting |
NCT02874339 -
High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema
|
N/A | |
| Not yet recruiting |
NCT05497986 -
Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure
|
N/A | |
| Completed |
NCT01987661 -
The Effects of Airtrapping on Sleep and Breathing in Non Invasive Ventilation (NIV) in COPD
|
N/A | |
| Terminated |
NCT03353064 -
Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure
|
N/A | |
| Completed |
NCT04072848 -
Mathematically Arterialised Testing of Hypercapnic Subjects Study
|
||
| Not yet recruiting |
NCT04131660 -
Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation
|
N/A | |
| Completed |
NCT02699112 -
Cardiac and Respiratory Function With Non-invasive Ventilation
|
||
| Completed |
NCT01523470 -
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure
|
Phase 3 | |
| Active, not recruiting |
NCT04709562 -
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
|
N/A | |
| Not yet recruiting |
NCT06064409 -
Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
|
||
| Recruiting |
NCT04351906 -
Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome
|
N/A | |
| Not yet recruiting |
NCT06367686 -
Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
|
||
| Completed |
NCT03406572 -
Use of Nasal High Flow Oxygen During Breaks of Non-invasive Ventilation for Patients With Hypercapnic Respiratory Failure
|
N/A | |
| Active, not recruiting |
NCT03364946 -
High Flow Therapy in ICUs Across Ibero America
|
||
| Not yet recruiting |
NCT06257667 -
Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients
|
N/A |