Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05690698 |
Other study ID # |
QHMHD |
Secondary ID |
|
Status |
Completed |
Phase |
Phase 3
|
First received |
|
Last updated |
|
Start date |
April 9, 2023 |
Est. completion date |
July 15, 2023 |
Study information
Verified date |
March 2023 |
Source |
Alexandria University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
In population of intensive care unit (ICU), most studies compared atypical antipsychotics
such as quetiapine with the traditional haloperidol in delirious patients of various forms
and etiologies. The role of such agents in patients with hyperactive is not fully understood.
This study compares the effectiveness of quetiapine with haloperidol in treating the
hyperactive form of delirium in terms of their effects on morbidity, length of stay in the
intensive care unit, and mortality in critically ill patients.
Description:
A common complication in the intensive care unit (ICU) that has recently been identified is
delirium. Defining delirium as a "sudden deterioration in attention, awareness, and
cognition, which is not explained by any pre-existing neurocognitive disorder, but because of
another medical condition," the Diagnostic and Statistical Manual of Mental Disorders (DSM-V)
clarified the definition of delirium.
A dibenzothiazepine derivative with a novel and distinctive pharmacologic profile is
quetiapine. The limbic system is overactive in delirium, which is one of its
pathophysiologies. By obstructing the mesolimbic dopamine D2 receptors specifically,
quetiapine may be able to regulate this hyperactivity.
The objective of this study is to compare the effectiveness of quetiapine with haloperidol in
treating the hyperactive form of delirium in terms of their effects on morbidity, length of
stay in ICU, and mortality in critically ill patients.
This research will not receive any grants, funding, or financial aid (NOT FUNDED STUDY).
Collaborators declare that they have no conflicts of interest.