Clinical Trials Logo

Clinical Trial Summary

The study examines interactions between fluid availability in the gut and fluid retention in the body. The relative rate of fluid uptake, the expansion of the plasma volume, and percent of fluid retained by the body will be measured in response to ingestion of beverages of different composition. Healthy, euhydrated adults will be studied. The results will help establish formulations of beverages that sustain if not promote acute euhydration.


Clinical Trial Description

Using a randomized order for beverage treatments at three separate trials, subjects will ingest 1 Liter of one of three beverages in 10 minutes: water, a beverage with 2.5% glucose with 45 mmol sodium/L, or a beverage with 1.7% glucose with 60 mmol sodium/L. Before and repeatedly for 2 h after ingestion of the beverage, blood samples will be drawn for assessments of D2O, Hb, Hct, osmolality, sodium, and glucose. The rate of appearance of D2O will be evaluated using the area under the curve, the slope of the appearance, and half time to plateau. Comparisons will be made between beverages for indices of the rate of appearance of D2O, the change in PV over time, and cumulative urine excreted. The cumulative urine produced will be used to calculate a modified BHI for the two glucose-electrolyte beverages and water for comparison with 1.0 (expected for no beverage effect). We hypothesize faster absorption (D2O appearance rate), and better overall hydration (expanded PV and higher modified BHI) will occur for beverages containing glucose and sodium compared to water. Further, we hypothesize that of the electrolyte beverages, the beverage with higher sodium content will promote greater overall hydration (less urine excreted) than the beverage with lower sodium. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05111392
Study type Interventional
Source University of Illinois at Chicago
Contact
Status Completed
Phase Phase 1/Phase 2
Start date September 3, 2021
Completion date November 30, 2022

See also
  Status Clinical Trial Phase
Not yet recruiting NCT04079543 - NPO and Patient Satisfaction in the Cath Lab N/A
Recruiting NCT06063655 - Effects of Two Novel Hydration Beverage Formulas on Rehydration in Adults N/A
Terminated NCT02486224 - Metabolomic Analysis of the Impacts of Hydration Status on Exercise Performance N/A
Recruiting NCT02249845 - Comparing the Diagnostic Accuracy of Clinical Dehydration Scales Among Small Children N/A
Completed NCT01285713 - IV Glucose for Dehydration Treatment Phase 2
Withdrawn NCT00691275 - Efficacy Study of IV Fluids Only vs Ondansetron to Treat Dehydration N/A
Completed NCT00360204 - Improving Health Outcomes for New Mothers and Babies Phase 3
Completed NCT00370968 - Zinc-ORS in Severe and Complicated Acute Diarrhea Phase 2/Phase 3
Completed NCT04076995 - INDIGO-2: The Effect of High Water Intake on Glucose Regulation in Low-drinkers N/A
Recruiting NCT05768789 - Buoy Electrolyte Study on Hydration Status of Active Men and Women N/A
Not yet recruiting NCT05428228 - Clinical Study to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults N/A
Completed NCT04997031 - Tap Water Intake and Perceptions in US Latinx Adults
Completed NCT04536324 - The Absorption Rate of Subcutaneous Infused Fluid
Completed NCT02926989 - Intravenous Fluids in Hospitalised Children Phase 4
Completed NCT04874584 - Culturally Tailored Nurse Coaching Study for Cancer Symptom Management N/A
Completed NCT02265575 - Hylenex-Assisted Resuscitation in Kenya (HARK) Trial for the Management of Dehydration Phase 2
Completed NCT02206581 - Using Hydration Monitor to Detect Changes in the Hydration Status Athletes N/A
Completed NCT01893853 - Fluid Balance During Exercise in the Heat With Water, Flavored Placebo, or a Carbohydrate-electrolyte Beverage Intake (The APEX Study) N/A
Completed NCT01503996 - Drinking Habits of Glaucoma Patients and Age Matched Controls N/A
Completed NCT01507129 - Biomarkers for Noninvasive Assessment of Human Hydration N/A