Hodgkin's Disease Clinical Trial
Official title:
Prediction of the Response to Chemotherapy by Tomoscintigraphie the MIBI in the Balance Sheet Pre Hodgkin's Disease and Lymphoma Malins High Grade
Predicting response to chemotherapy in patients with Hodgkin's disease or lymphoma
high-grade malignant de novo or recurrence.
The non-Hodgkin's lymphoma and high-grade Hodgkin's disease may show resistance to
chemotherapy, regardless of their initial extension. The failure of treatment is most often
correlated with an incomplete answer or lack of response to chemotherapy as a result
chemoresistance. This drug, which may involve the gene MDR1 (multidrug resistance) encoding
the protein PGP, can be studied in vivo by MIBI scan. The MIBI is behind a tracer
perfusionnel used routinely to explore myocardial perfusion, but it has other
characteristics of fixing, which can be used in oncological imaging (fixation by glial
tumors of high grade).Prospective Study, which includes conducting a tomoscintigraphie 30
minutes after injection of 20 mCi of 99mTc-MIBI in initial stock or relapse of high-grade
lymphoma and Hodgkin's disease any stage (I-IV). Fixing the MIBI is compared with
morphological abnormalities detected by CT and the setting of lesions by 18FDG. Patients
will be treated in a traditional way, without changes in treatment protocols used in
routine. Patients with a negative MIBI scan, will be watched with particular attention in
order to detect insufficient response to chemotherapy. The only change, the care of
patients, only for the achievement of an initial consideration of non-invasive imaging,
further, which is the tomoscintigraphie the MIBI. Of the tumor samples, will be evaluated by
immunohistochemistry, the expression of PGP and the MRP1 (two proteins associated with the
drug). On blood, may be carried out genotyping of MDR1, MRP1 and MRP2 to the patient.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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