HIV Clinical Trial - SEARCH SAPPHIRE Phase B

Status Recruiting

Clinical Trial Summary

This study will evaluate the effects of optimized dynamic prevention and treatment packages delivered in a precision community health model on HIV incidence, as well as other health outcomes, in a community randomized trial design.

Clinical Trial Description

In the "evaluation" Phase B, the SEARCH SAPPHIRE study will evaluate the effects of Dynamic Prevention and Dynamic Treatment intervention packages based on data from Phase A (NCT04810650) and new advances from outside the study delivered in a precision community health model, on HIV incidence and other health outcomes, in a pair-matched community randomized design. The Phase B precision community health intervention will consist of a three part intervention: 1) Community-enhanced reach activities 2) Person-centered care delivery; and, 3) Data-enhancement to improve precision of interventions. The study hypothesis for the Phase B population level study is: A Precision Community Health Model leveraging existing facility-based outreach and community health workers, enabled by dynamic choice prevention/treatment multi-disease approaches and interactive data systems -will reduce HIV infections, deaths and improve health. Structured stakeholder consultations are formally incorporated in the study design and leverage regular and ongoing collaborations the study team has with the HIV, non-communicable disease and general health leads in Kenya and Uganda Ministries of Health and PEPFAR implementing partners at the national and the regional level. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05768763
Study type	Interventional
Source	University of California, San Francisco
Contact	Tamara Clark, MHS
Phone	628-206-8790
Email	tamara.clark@ucsf.edu
Status	Recruiting
Phase	N/A
Start date	March 28, 2023
Completion date	June 2026

View Details

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