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Ambispective Cohort Study to Evaluate the Efficacy, Safety, and Tolerance of an Antiretroviral Regimen With Doravirine

Hiv Clinical Trial

Official title:
Ambispective Cohort Study to Evaluate the Effectiveness, Safety and Tolerance of a Doravirine-based Antirretroviral Regimen as a Switching Strategy in Virologically Supressed HIV Infected Patients: Real-world Data

Clinical Trial Summary

Observational, ambispective single-center cohort study, including 150 patients who received or are receiving a doravirine-based regimen plus two NRTI or a dual therapy of doravirine plus dolutegravir (DTG) or bDRV in routinely clinical practice.

Clinical Trial Description

Observational, ambispective single-center cohort study, including 150 patients who received or are receiving a doravirine-based regimen plus two NRTI or a dual therapy of doravirine plus dolutegravir (DTG) or bDRV in routinely clinical practice. All patients who were switched to a doravirine-based regimen from date of its availability in the center (September 2020) due to clinical considerations and have available records will be retrospectively included until date of study approval (expected on July 2021). Minor resistances in a basal genotype to NNRTI or previous failure to NNRTI as nevirapine or efavirenz will be accepted if doravirine it is combined with a high genetic barrier drug with complete activity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05140603
Study type Observational
Source Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Contact Nuria Espinosa Aguilera
Phone 955 01 30 98
Email nuriai.espinosa.sspa@juntadeandalucia.es
Status Not yet recruiting
Phase
Start date December 1, 2021
Completion date October 1, 2023
View Details
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