HIV Clinical Trial
Official title:
Peer Delivery of HIV Self-Screening to Support Linkage to HIV Prevention in Rural KwaZulu-Natal, South Africa: A Cluster Randomized Control Trial
Hypothesis: HIV-Self-Test (HIV-ST) will allow peers or peer-networks to effectively and
efficiently link older adolescent girls and young women into HIV prevention and care
services.
Design: A cluster randomized control trial comparing two models of peer delivery of HIV-ST,
through incentivized respondent driven peer networks and direct distribution by peer
navigators compared to standard of care (referral to HIV testing, prevention and care
services by peer navigators) in improving the uptake of HIV prevention and care amongst young
women (18-24) living in the rural uMkhanyakude district of KwaZulu-Natal, South Africa.
Objectives:
1. To increase the knowledge of HIV status among young women aged 18-24 years old through
distribution of HIV-ST through incentivized peer networks or direct distribution by peer
navigators compared to peer navigators referring into HIV testing services.
2. To determine an increase in the rate of linkage among young women aged 18-24 to HIV
prevention and treatment services facilitated by distribution of HIV-ST through
incentivized peer networks or direct distribution by peer navigators compared to peer
navigators referring into services.
3. To conduct a process evaluation of the acceptability, feasibility, and reach (out of
school, recently migrant and living in remote areas) in linking 18-24-year-old women to
HIV prevention and treatment services of HIV-ST distribution through incentivized peer
networks, or direct distribution by peer navigators or peer navigators referring into
services.
4. To measure the cost per 18-24-year-old linked to prevention and care through peer-led
incentivized HIV-ST delivery system or direct distribution of HIV-SS by peer navigators,
compared to peer navigator referring into services.
Primary Outcomes:
The difference between the rate of linkage within three months of 18-24 years old women to
HIV confirmatory testing and pre-exposure prophylaxis (PrEP) eligibility screening if
HIV-negative and antiretroviral treatment (ART) starting if HIV-positive. It will be between
the two peer-delivery approaches to HIV-ST distribution (incentivized HIV-ST delivery through
peer network and direct distribution of HIV-ST by peer navigators) compared to standard of
care (peer navigator referral to HIV testing, treatment and prevention services). Rate is
defined as the number of linkages per month of peer navigator outreach activity.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06162897 -
Case Management Dyad
|
N/A | |
Completed |
NCT03999411 -
Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients
|
Phase 4 | |
Completed |
NCT02528773 -
Efficacy of ART to Interrupt HIV Transmission Networks
|
||
Recruiting |
NCT05454839 -
Preferences for Services in a Patient's First Six Months on Antiretroviral Therapy for HIV in South Africa
|
||
Recruiting |
NCT05322629 -
Stepped Care to Optimize PrEP Effectiveness in Pregnant and Postpartum Women
|
N/A | |
Completed |
NCT02579135 -
Reducing HIV Risk Among Adolescents: Evaluating Project HEART
|
N/A | |
Active, not recruiting |
NCT01790373 -
Evaluating a Youth-Focused Economic Empowerment Approach to HIV Treatment Adherence
|
N/A | |
Not yet recruiting |
NCT06044792 -
The Influence of Primary HIV-1 Drug Resistance Mutations on Immune Reconstruction in PLWH
|
||
Completed |
NCT04039217 -
Antiretroviral Therapy (ART) Persistence in Different Body Compartments in HIV Negative MSM
|
Phase 4 | |
Active, not recruiting |
NCT04519970 -
Clinical Opportunities and Management to Exploit Biktarvy as Asynchronous Connection Key (COMEBACK)
|
N/A | |
Completed |
NCT04124536 -
Combination Partner HIV Testing Strategies for HIV-positive and HIV-negative Pregnant Women
|
N/A | |
Recruiting |
NCT05599581 -
Tu'Washindi RCT: Adolescent Girls in Kenya Taking Control of Their Health
|
N/A | |
Active, not recruiting |
NCT04588883 -
Strengthening Families Living With HIV in Kenya
|
N/A | |
Completed |
NCT02758093 -
Speed of Processing Training in Adults With HIV
|
N/A | |
Completed |
NCT02500446 -
Dolutegravir Impact on Residual Replication
|
Phase 4 | |
Completed |
NCT03805451 -
Life Steps for PrEP for Youth
|
N/A | |
Active, not recruiting |
NCT03902431 -
Translating the ABCS Into HIV Care
|
N/A | |
Completed |
NCT00729391 -
Women-Focused HIV Prevention in the Western Cape
|
Phase 2/Phase 3 | |
Recruiting |
NCT05736588 -
Elimisha HPV (Human Papillomavirus)
|
N/A | |
Recruiting |
NCT03589040 -
Darunavir and Rilpivirine Interactions With Etonogestrel Contraceptive Implant
|
Phase 2 |