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Decrease of Neuropsychiatric Side Effects After Switching From Atripla to Eviplera — DeepSwitch  

HIV Clinical Trial

Official title:
Decrease of Neuropsychiatric and Neurocognitive Side Effects Prevalence

Clinical Trial Summary

The aim of this prospective, open label study is to check for differences in neuropsychiatric and neurocognitive measurements among patients that will be switched from Atripla to Eviplera among 40 patients.

Clinical Trial Description

40 patients on Atripla for at least 12 weeks with undetectable HIV-1 viral load will be randomly assigned to one of two groups in a ratio of 1:1: half of the patients will be switched to Eviplera and half will remain on Atripla. Neuropsychiatric symptoms will be evaluated using specific questionnaires (anxiety and depression scales, sleeping quality scale, etc) and neurocognitive functions will be assessed using standard tests (Trail A and B, memory tests, etc). Patient satisfaction will be assessed using a visual analog scale. Treatment efficacy will be evaluated by measuring the rate of patients with HIV vilral load under 50 copies/mL. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02447016
Study type Interventional
Source Sheba Medical Center
Contact
Status Terminated
Phase Phase 4
Start date May 2015
Completion date December 21, 2016
View Details
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