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PrEP, Lube, and the Rectal Mucosa in MSM at Risk of HIV

HIV Clinical Trial

Official title:
Defining the Rectal Mucosa in Men Who Have Sex With Men at Risk of HIV Infection

Clinical Trial Summary

The purpose of this study is to determine whether the use of rectal lubricants can affect how well the medication, Truvada, will work to prevent infection with HIV when someone is exposed to HIV in the rectum.

Clinical Trial Description

Men who have sex with men (MSM) continue to be disproportionately affected by HIV. The majority of HIV infections among MSM occur through exposure to the rectal mucosa during receptive anal intercourse (RAI). During RAI, many MSM will use lubricants, which can potentially cause mucosal inflammation and damage. A new HIV prevention intervention, called pre-exposure prophylaxis (PrEP), recommends that MSM at risk of HIV infection take a daily anti-HIV medication called Truvada (tenofovir/emtricitabine) which is highly effective. However, it is not known if the use of lubricant during RAI will interfere with the efficacy of PrEP for HIV prevention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02401230
Study type Interventional
Source Emory University
Contact
Status Completed
Phase Phase 4
Start date March 2015
Completion date January 25, 2017
View Details
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