A Pilot Study of Triple NtRTI/NsRTI Therapy in Antiretroviral Naive HIV-1 Infected Patients

HIV Clinical Trial

Official title:

An Open, Single-Arm, Multi-Center, Phase IV Pilot Study of Treatment of Antiretroviral Naive HIV-1 Infected Patients With Tenofovir Disoproxil Fumarate in Combination With Emtricitabine and Zidovudine

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00199121
• Other study ID #: TEAZE001
• Status: Recruiting
• Phase: Phase 4
• First received: September 13, 2005
• Last updated: December 13, 2005

Study information

• Verified date: July 2005
• Source: Johann Wolfgang Goethe University Hospitals
• Contact: Schlomo Staszewski, MD
• Phone: +49 69 6301
• Email: stasz[@]hivcenter.de
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the antiviral effect and durability of antiviral response (HIV-1 RNA PCR) and safety of a triple NtRTI/NsRTI therapy in antiretroviral naive patients. Patients will receive TDF plus FTC plus AZT for at least 48 weeks. Further objectives are to evaluate resistance pathways in failing patients treated with TDF/FTC/AZT and to evaluate a treatment strategy of sparing PIs and NNRTIs for later treatment.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 0
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 18 years and older

• HIV-1 positive

• antiretroviral treatment naive

• one CD4 count >200/ul within 14d prior to study drug administration

• one HIV-1 RNA PCR value >5000 and <100.000 cop/ml within 14d prior to study drug administration

• women of child bearing potential: negative serum pregnancy test within 14d of study

• ability to understand and provide written informed consent

• overall stable disease

• absence of clinical signs of lipodystrophy

Exclusion Criteria:

• alcohol or illicit drug use

• malabsorption syndrome or other gastrointestinal dysfunction

• clinically relevant pancreatitis/hepatitis within the last 6 months

• receiving other investigational drugs

• abnormal hemoglobin, neutrophil, platelet, AST/ALT, pancreatic amylase, creatinine clearance, total bilirubine levels within 14d prior to study

• pregnancy/breast-feeding

• radiation therapy or cytotoxic chemotherapeutic agents within 30d of study

• prior antiretroviral therapy at any time, investigational antiretrovirals trial at any time, HIV vaccine within 90d prior to study

• immunomodulating agents

• serious medical condition (diabetes, congestive heart failure, cardiomyopathy, or other cardiac dysfunction)

• active diagnosis of AIDS (except for cutaneous Kaposi Sarcoma)

• foscarnet therapy or other agent with documented activity against HIV-1

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• HIV

Intervention

Drug:
• Zidovudine (drug)

Locations

Country	Name	City	State
Germany	HIV Treatment & Research Unit, Dept. of Internal Medicine II, Hospital of the Johann Wolfgang Goethe University Frankfurt/Main	Frankfurt/Main	Hesse

Sponsors (2)

Lead Sponsor	Collaborator
Johann Wolfgang Goethe University Hospitals	Gilead Sciences

Country where clinical trial is conducted

Germany,