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Pharmacokinetic Drug Interaction Study Between Raltegravir and Atorvastatin. — AVIATOR  

HIV Clinical Trial

Official title:
Pharmacokinetic Drug Interaction Study Between Raltegravir and Atorvastatin (AVIATOR).

Clinical Trial Summary

Dyslipidemia is highly prevalent among patients with HIV infection and contributes to the increased cardiovascular disease risk in this patient population. Atorvastatin lowers plasma low-density lipoprotein (LDL) cholesterol levels and is used for prevention of artherosclerotic disease. Raltegravir, an HIV integrase inhibitor, could be one of the preferred antiretroviral agents in HIV patients with dyslipidemia because it has a beneficial lipid profile. Theoretically, no clinically relevant drug interaction is expected between atorvastatin and raltegravir. However, atorvastatin and raltegravir share similar metabolic pathways which could be relevant in the occurrence of pharmacokinetic interactions. In order to be able to recommend raltegravir and atorvastatin concomitant use, a pharmacokinetic study in healthy volunteers is proposed.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01779687
Study type Interventional
Source Radboud University
Contact
Status Completed
Phase Phase 1
Start date March 2013
Completion date August 2013
View Details
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