Saquinavir/Ritonavir in Single Therapy as Maintenance Treatment

HIV Infections Clinical Trial

Official title:

Open-label, Comparative and Randomised Pilot Study to Evaluate the Efficacy and Safety of Saquinavir/Ritonavir in Single Therapy vs Standard HAART Therapy as Maintenance Therapy.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00379405
• Other study ID #: SQV/RTV-MONOTERAPIA
• Secondary ID: 2006-001136-47
• Status: Completed
• Phase: Phase 4
• Start date: June 2006
• Est. completion date: July 2008

Study information

• Verified date: December 2019
• Source: Germans Trias i Pujol Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Study the efficacy of Saquinavir/Ritonavir when given in single therapy as maintenance therapy, compared to standard HAART therapies.

Description:

Different therapeutic strategies have been investigated to improve adherence to treatment and reduce toxicity. Both the reduction in the number of doses and the number of daily tablets have led to an improvement in therapeutic compliance. Similarly, the administration of new treatment regimens with a reduced number of tablets a day and without NTRI may be clinically useful in improving compliance with HAART and limiting NTRI-associated toxicity. These would comprise combinations of a PI, boosted with ritonavir, plus a non-Nucleoside and single therapy with PIs boosted with ritonavir.

In this regard, the results obtained with lopinavir/ritonavir and with atazanavir/ritonavir are very promising and open up a possible channel of research with other PIs boosted with low doses of ritonavir.

There are other PIs whose antiretroviral efficacy has also been demonstrated, such as saquinavir, but whose economic cost is much lower. Furthermore, saquinavir has a low toxicity profile, and the availability of saquinavir 500 mg facilitates comfortable administration, since it makes it possible to reduce the number of daily tablets to more than half.

Moreover, it is important to take into account that the incidence of mutations that confer resistance to saquinavir on patients that fail on combinations including this PI is very low, which makes it possible to reuse the drug in future treatment regimens or salvage patients with other PI All these characteristics (high intrinsic potency, low number of tablets, low toxicity, low potential of selection of resistant viral strains in combination with ritonavir, and low economic cost) make single therapy with the new formulation of saquinavir, boosted with low doses of ritonavir, a possible therapeutic option as maintenance strategy in HIV-infected patients with maintained suppression of the viral load.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: July 2008
• Est. primary completion date: May 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Patients infected by HIV-1 (at least one documented positive Western-Blot).

• Age > 18 years.

• Patients on antiretroviral treatment (standard HAART therapy) for at least six months.

• HIV-1 plasma viral load <50 copies/mL (documented in at least two determinations performed over the six months prior to the inclusion visit).

• Patients without evidence of previous virological failure to IP

• Absence of opportunistic infections and/or tumours in the three months prior to inclusion.

• Subject able to follow the treatment period, without any suspicion of poor adherence during previous antiretroviral treatments.

• Signature of the informed consent.

Exclusion Criteria:

• Suspicion of unsuitable antiretroviral treatment compliance.

• Documented existence of any of the primary mutations in the protease gene or 3 or more of the following: L10F/I/R/V, K20M/R, M36I/V, I54L/T/V, L63P, A71T/V , V82A/F/T/S, I84A/V OR L90M.

• Known allergic hypersensitivity to any of the investigational drugs or any similar drug.

• Hepatic tests (AST, ALT, GGT) > or equal to 5 times the upper limit of normality during the three months prior to the screening visit

• Presence of renal impairment (creatinine > or equal to 1.5 times the upper limit of normality).

• Pregnancy or breastfeeding. Refusal to use reliable contraceptive methods during the study period.

• Participation in another clinical trial wich entail the antiretroviral treatment modification.

Related Conditions & MeSH terms

• HIV Infections

Intervention

Drug:
• Saquinavir/Ritonavir : 2 capsules (500 mg) / 12 hours
Saquinavir/Ritonavir: 2 capsules (500 mg) / 12 hours

Locations

Country	Name	City	State
Spain	Germans Trias i Pujol University Hospital	Badalona	Barcelona
Spain	Hospital del Sant Pau.	Barcelona

Sponsors (2)

Lead Sponsor	Collaborator
Germans Trias i Pujol Hospital	Fundacio Lluita Contra la SIDA

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Virological response: Viral Load		weeks 24 and 48
Secondary	CD4 and CD8 lymphocyte count.		weeks 24 and 48
Secondary	Physical Exploration: including weight, height, index waist/hip (the abdominal perimeter is measured between the last floating rib and the iliac crest), assessment of changes in body fat distribution,...		weeks 24 and 48
Secondary	Karnofsky Index.		weeks 24 and 48
Secondary	Adverse events.		during the 48 weeks of follow-up
Secondary	Trough plasma concentrations of Saquinavir.		during the 48 weeks of follow-up
Secondary	Lipid study in plasma (total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides)		during the 48 weeks of follow-up
Secondary	Serology for Hepatitis B and C virus.		at baseline visit
Secondary	Assessment of treatment adherence.		at baseline and weeks 4, 12, 24, 36 and 48
Secondary	Assessment of quality of life (by means of the MOS-HIV questionnaire).		at baseline and weeks 4, 12, 24, 36 and 48
Secondary	Genotype if virological failure.		at any time of study if it is necessary