HIV Infections Clinical Trial
Official title:
Genomics: A Substudy of a Large, Simple Trial Comparing Two Strategies for Management of Anti-Retroviral Therapy (The SMART Study)
The purpose of this study is to collect blood samples from SMART study participants to use in future genetic studies.
Despite progress in the treatment of HIV and a greater understanding of the pathophysiology
of HIV infection, there are still unexplained differences in both the progression of
untreated HIV infection and response to antiretroviral therapy. These differences are likely
related to the unique genetic makeup of individuals with HIV infection. Particular genes may
offer protection against HIV infection, while other genes may make disease progression more
likely. Knowing more about the genetic makeup of HIV infected individuals may lead to the
development of a targeted treatment strategy based on an individual's specific risk of
disease progression and sensitivity to medication toxicity. The purpose of this substudy is
to collect blood samples from SMART study participants. The samples will be used in future
Community Programs for Clinical Research on AIDS (CPCRA) studies investigating the link
between human genetic factors and clinical outcome data.
This study will enroll individuals currently participating in the SMART study. Participants
will provide one blood sample. Individual test results from future blood analyses will not
be provided to a patient unless they may have profound health implications for that patient.
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N/A
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