Pilot Study Evaluating Interruption of Enfuvirtide (Fuzeon, T20) in Patients With Enfuvirtide Resistance

HIV Infections Clinical Trial

Official title:

Partial Treatment Interruptions in HIV-1 Patients With Multi-Drug Resistant Virus

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00187551
• Other study ID #: H8211-18804-05
• Status: Completed
• Phase: Phase 4
• First received: September 13, 2005
• Last updated: February 8, 2011
• Start date: May 2000
• Est. completion date: November 2005

Study information

• Verified date: June 2006
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The goal of this study is to examine whether enfuvirtide (T20, Fuzeon) has continued anti-HIV activity in patients experiencing an incomplete virologic response to an enfuvirtide-based regimen.

Description:

Some patients do not achieve an undetectable HIV viral load with an enfuvirtide (T20, Fuzeon) based antiretroviral regimen. As a consequence, enfuvirtide resistant virus can emerge. It is not yet known if enfuvirtide has continued virologic or immunologic benefit after the drug-resistant variant emerges. Interrupting enfuvirtide may reduce the accumulation of enfuvirtide mutations and may allow for a potent response of enfuvirtide with future regimens.

Subjects must have evidence of viral replication (HIV RNA > 1,000 copies/ml on two consecutive measurements) while on a stable antiretroviral regimen containing enfuvirtide. Patients will then interrupt enfuvirtide while continuing all other antiretroviral agents. Subjects will be seen weekly for four weeks, every two weeks for an additional 8 weeks, and then every four weeks through week 48.

Plasma HIV RNA levels and CD4+/CD8+ T cell counts will be measured in real time at each visit, and provided to the referring primary care physician. Subjects will be allowed to resume enfuvirtide at any time during the course of this study. Subjects will be encouraged to resume enfuvirtide (with or without modifying the background regimen) if plasma HIV RNA levels increase by > 0.5 log on two consecutive occasions. Subjects are seen every four weeks for 24 weeks after enfuvirtide is resumed.

Plasma will be collected at those visits for HIV RNA and stored for retrospective genotype/phenotype evaluation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: November 2005
• Est. primary completion date: November 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Currently receiving continuous enfuvirtide-based antiretroviral therapy.

• Documentation of recent plasma HIV RNA level greater than the lower limit of detection (measured within the preceding 4 weeks)

• Screening plasma HIV-1 RNA level > 1000 copies/mL.

• Negative serum pregnancy test (for women of childbearing potential) documented within the 14-day period prior to study entry.

• Subjects must be able to give written informed consent and agree to abide by the requirements of the study.

Exclusion Criteria:

• Unstable HIV disease status such that interrupting any antiretroviral therapy poses significant short-term risk for disease progression (as determined by study investigators and referring primary care provider).

• Female subjects who are pregnant, breastfeeding, or who plan to become pregnant during the study.

• Active hepatitis C infection requiring treatment with an interferon-based regimen.

• Evidence of active, untreated opportunistic infections or unexplained temperature which is > 38.5°C for seven consecutive days, within 30 days prior to the first screening visit.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• HIV Infections

Intervention

Other:
• Interruption of enfuvirtide
treatment interruption
• enfuvirtide interrupton
enfuvitide will be interrupted in patients harboring resistant virus

Locations

Country	Name	City	State
United States	San Francisco General Hospital	San Francisco	California

Sponsors (2)

Lead Sponsor	Collaborator
University of California, San Francisco	Universitywide AIDS Research Program

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	CD4		week 24	Yes