HIV-infection/Aids Clinical Trial
Official title:
Novel Measures and Theory of Pediatric Antiretroviral Therapy Adherence in Uganda
Current measures of adherence detect problems weeks to months after they occur. Because the
HIV virus rapidly begins replicating and mutating in the absence of effective antiretroviral
therapy, treatment failure may develop before an intervention can be deployed. Real-time
objective adherence monitoring could redirect efforts from a reactive response to the
proactive prevention of treatment failure. Because adherence is so closely associated with
viral suppression, accurate adherence monitoring could also strategically limit viral
monitoring only to those patients at a defined risk for viral rebound.
This observational study is assessing a wireless adherence monitoring device and mobile
phone-based adherence data collection among caregivers of children under the age of ten
years in Mbarara, Uganda. It involves both quantitative and qualitative measures of the
feasibility and acceptability of these measures, as well as circumstances of adherence
lapses and other individual and cultural factors affecting adherence. The qualitative data
will be used to explore models of adherence behavior, which will likely include the
child-caregiver dynamic, the child's mental and physical health, and social support
mechanism.
See above. ;
Observational Model: Cohort, Time Perspective: Prospective
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