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Role of Exogenous and Endogenous Sex Hormones on Tenofovir and Emtricitabine Disposition in Female Genital Tract

HIV/AIDS Clinical Trial

Official title:
Role of Exogenous and Endogenous Sex Hormones on Tenofovir and Emtricitabine

Clinical Trial Summary

Cervical biopsies will be collected from women aged 18 and over whom are virally suppressed and taking tenofovir as part of their antiretroviral therapy regimen. Blood plasma, peripheral blood mononuclear cells (PBMC), and cervicovaginal swabs will also be collected. Drug concentrations, hormone concentrations, inflammatory cytokines, and vaginal microbiome will be evaluated to understand the role of hormones, inflammation, and the microbiome in modulating drug efficacy in the female genital tract.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03218085
Study type Observational
Source University of Minnesota
Contact
Status Completed
Phase
Start date July 14, 2017
Completion date February 15, 2024
View Details
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