High Blood Pressure Clinical Trial
Official title:
The Effect of Aortic Impedance on Myocardial Relaxation
Verified date | February 2019 |
Source | University of Wisconsin, Madison |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic stiffness?
Status | Completed |
Enrollment | 17 |
Est. completion date | December 20, 2006 |
Est. primary completion date | December 20, 2006 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - Subjects over the age of 65 Exclusion Criteria: - Have known or suspected coronary artery disease - Have known or suspected left ventricular dysfunction - Have significant valvular, infiltrative, pericardial, or congenital heart disease - Have a resting systolic blood pressure < 100 mmHg - Have had an adverse reaction to nesiritide or hydralazine - Have a serum creatinine > 2 mg/dl at Visit 1 |
Country | Name | City | State |
---|---|---|---|
United States | University of Wisconsin Hospital & Clinics | Madison | Wisconsin |
Lead Sponsor | Collaborator |
---|---|
University of Wisconsin, Madison | Scios, Inc. |
United States,
Sweitzer NK, Hetzel SJ, Skalski J, Velez M, Eggleston K, Mitchell GF. Left ventricular responses to acute changes in late systolic pressure augmentation in older adults. Am J Hypertens. 2013 Jul;26(7):866-71. doi: 10.1093/ajh/hpt043. Epub 2013 Mar 28. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | heart myocardium relaxation (diastole) | before and after administration of vasodilator medication |
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---|---|---|---|
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