Capsule Microbiota Transplant Therapy for Hidradenitis Suppurativa

Status Recruiting

Clinical Trial Summary

HS is relatively common in the United States with a prevalence of 0.1-1.0%. 1 HS has a dramatic impact on quality of life, significantly more so than other chronic skin diseases, such as psoriasis or atopic dermatitis (AD). HS also has a large economic impact, due to frequent emergency department and inpatient care utilization, and re-hospitalization rates similar to congestive heart failure. Unfortunately, few treatment options are effective. There is only one currently FDA-approved treatment, adalimumab, but only 40- 60% respond to treatment and over 50% lose response within one year . The overarching goal of this pilot study is to investigate the central hypothesis that oral microbiota transplant therapy(MTT) alters the gut microbiome in patients with Hidradenitis Suppurativa (HS), influencing cutaneous microbiota via systemically absorbed gut-derived metabolites.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06058520
Study type	Interventional
Source	University of Minnesota
Contact	Gretchen Bellefeuille
Phone	612-626-0249
Email	belle116@umn.edu
Status	Recruiting
Phase	Early Phase 1
Start date	October 1, 2023
Completion date	January 1, 2025

View Details

See also
Status	Clinical Trial	Phase
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Completed	`NCT03628924` - A Study to Evaluate the Efficacy, Safety, and Tolerability of Guselkumab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa (HS)	Phase 2
Not yet recruiting	`NCT05531747` - Replicative Stress in Hair Follicle Stem Cells and Pathogeny of Hidradenitis Suppurativa	N/A
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