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Clinical Trial Summary

The study evaluates the efficacy of an adapted antibiotherapy in Hurley stage 2 active Hidradenitis Suppurativa patients versus tetracycline derivative


Clinical Trial Description

The antibiotic strategy is targeted against specific pathobionts which have been identified in HS lesions by the investigator's team. Half of participants will receive a 3-week course of ceftriaxone + metronidazole treatment followed by 3 weeks of rifampicin + moxifloxacin + metronidazole combination, then 6 weeks of rifampin + moxifloxacin (experimental groupe), versus a 12 weeks course of lymecycline (control group) Double blind treatment phase will stop at week 12. All patients whatever their randomization arm or their remission status will begin follow-up treatment according to standard care recommendations (Société Française de Dermatologie): lymecycline, doxycycline or cotrimoxazole. Prescription will be upon decision of the investigator. This maintenance treatment is not experimental. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05821478
Study type Interventional
Source Institut Pasteur
Contact Maïa Delage-Toriel, MD
Phone +33 1 40 61 30 77
Email maia.delage-toriel@pasteur.fr
Status Not yet recruiting
Phase Phase 3
Start date April 15, 2024
Completion date September 15, 2026

See also
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