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Botulinum Toxin Therapy in Hidradenitis Suppurativa — HS  

Hidradenitis Suppurativa Clinical Trial

Official title:
Targeting Nociceptors in Hidradenitis Suppurativa

Clinical Trial Summary

This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS). In this study, the investigators will test the hypothesis that inhibiting neuropeptide activity with botulinum toxin reduces pathogenic inflammation.

Clinical Trial Description

Botulinum toxin prevents vesicle fusion at nerve terminals thereby inhibiting neuropeptide release. The investigators will collect punch biopsies of lesional skin from HS patients before, and 1-2 months after botulinum toxin treatment (50U per axilla in 10 injections of 0.1mL) then perform flow cytometric, transcriptomic, and microscopic analysis of skin to determine if nonselective inhibition of neuropeptide release diminishes IL-17 driven skin inflammation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05403710
Study type Observational
Source University of Massachusetts, Worcester
Contact Sarah K Whitley, MD PhD
Phone (508)334-5979
Email sarah.whitley@umassmed.edu
Status Recruiting
Phase
Start date June 7, 2022
Completion date April 30, 2028
View Details
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