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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03668925
Other study ID # PJ12076
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date May 1, 2013
Est. completion date September 1, 2015

Study information

Verified date August 2018
Source CHU de Reims
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Hidradenitis suppurativa is a chronic dermatosis, characterized by an inflammation of the follicular epithelium in the apocrine glands.

The hypothesis of a link between hidradenitis suppurativa and inflammatory rheumatism has been widely considered, with evidence in support of this theory accumulating from several case reports and small series. The most frequently cited rheumatismal disease thought to be associated with Hidradenitis suppurativa is spondyloarthritis.

Taken together, these data suggest that there may a link between hidradenitis suppurativa and spondyloarthritis, but literature data are sparse, and to date, no study has investigated or demonstrated such a relation. Indeed, existing studies to date were observational, descriptive, and retrospective, and did not use modern diagnostic approaches for documenting spondyloarthritis, such as magnetic resonance imaging (MRI) or the recent classification of spondyloarthritis.


Description:

The aim of the study was to test the hypothesis that the risk of spondyloarthritis is increased in patients with hidradenitis suppurativa.


Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date September 1, 2015
Est. primary completion date April 1, 2014
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- for case: patients with diagnosis of hidrosadenitis suppurativa in the Department of Dermatology of the University Hospital of Reims, regardless of the stage of severity and duration of their disease

- for control: patients without diagnosis of hidrosadenitis suppurativa matched to cases for age (±5 years) and sex

- for case and control: have accepted to take part in the research

Exclusion Criteria:

- for case and control: age <18 years old

Study Design


Related Conditions & MeSH terms


Intervention

Radiation:
magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement
magnetic resonance imaging (MRI) of the sacro-iliac region HLA B27 test C-reactive protein (CRP) measurement

Locations

Country Name City State
France Damien JOLLY Reims

Sponsors (1)

Lead Sponsor Collaborator
CHU de Reims

Country where clinical trial is conducted

France, 

References & Publications (1)

Fauconier M, Reguiai Z, Barbe C, Colosio A, Eschard JP, Salmon JH, Direz G. Association between hidradenitis suppurativa and spondyloarthritis. Joint Bone Spine. 2017 Sep 28. pii: S1297-319X(17)30164-1. doi: 10.1016/j.jbspin.2017.09.005. [Epub ahead of print] — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary spondyloarthritis spondyloarthritis was diagnosed by a rheumatologist using the Assessment of SpondyloArthritis international Society (ASAS) criteria Day 0
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