Heroin Addiction Clinical Trial
Official title:
Decision Making Deficit and DNA Methylation in Opioid Receptor Genes Among Community Heroin Addicts
Heroin addiction has emerged as a serious problem with tremendous impacts on the addicts and
the society. Since the introduction of opioids substitutive treatment in 2006, more than
30,000 heroin addicts had received treatment, and nearly 12,000 continued on treatment
currently. However, an unknown proportion of patients hidden in community remained
un-treatment. To motivate the community heroin addicts is thus a challenging task.
It is suggested that decision making deficit is core feature which determine outcomes and
treatment motivations in patients with addiction disorders. Recently, the state-of-the-art
development of epigenetics uncover that environmental modification, via altering level of
DNA methylation and gene expression will influence on neurocognitive functioning.
Via respondent-driven sampling, this study aims to recruit a representative sample targeting
at the hard-to-reach community heroin addicts. The goal of this study is to identify the
clinical feature as well as decision making-related neurocognitive deficit in these
patients. Moreover, the investigators will explore the interplay of clinical features, DNA
methylation and gene expressions on opioids receptor genes. The findings will help to
clarify the clinical characteristics of community heroin addicts, to uncover the links
between DNA methylation and clinical features of heroin addiction and to develop modifiable
treatment targets in the future.
n/a
Observational Model: Case-Only, Time Perspective: Cross-Sectional
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