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Hernia, Hiatal clinical trials

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NCT ID: NCT04152798 Completed - Clinical trials for Gastroesophageal Reflux Disease

Approach to Hiatal Hernia Repair Based on Collagen Study

Start date: January 1, 2014
Phase: N/A
Study type: Interventional

Groups of patients who underwent laparoscopic repair of large hiatal hernias by primary posterior crural repair and crural repair with ProGrip™ mesh techniques were examined for recurrence rate of hiatal hernias, quality of life according to the GERD-HRQL questionnaire. Clinical evaluation was performed at 3, 6, 12, 24, 36, and 48 months after surgery.

NCT ID: NCT04096170 Recruiting - Clinical trials for Hernia, Paraesophageal

Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo

PEH
Start date: June 21, 2018
Phase: Phase 4
Study type: Interventional

We aim to study the impact of perioperative IV lidocaine on postoperative pain control in patients undergoing paraesophageal hernia repair. This is in the context of an established ERAS protocol. We wish to study the effect of IV Lidocaine on postoperative short and long-term outcomes, including patients' length of stay postoperative mortality, morbidity, and quality of life. We will compare this to our standard pain management.

NCT ID: NCT04007952 Completed - Clinical trials for Paraesophageal Hernia

Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair

Start date: June 26, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effect of anterior gastropexy (one or more sutures fixing the stomach to the inner abdominal wall) on improving durability of paraesophageal hernia repair. Half of participants will receive anterior gastropexy, while the other half will not. The hypothesis is that anterior gastropexy will help to prevent paraesophageal hernias from recurring.

NCT ID: NCT03776669 Recruiting - Morbid Obesity Clinical Trials

Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients

Start date: January 9, 2019
Phase: N/A
Study type: Interventional

Background: Obesity and hiatal hernia are both risk factors of gastroesophageal reflux disease (GERD), and the incidence of hiatal hernia is much higher in morbidly obese patients. Many believe that higher intra-abdominal pressure with higher esophagogastric junction (EGJ) pressure gradient in morbidly obese patients is the main mechanism accounting for the occurrence of GERD. Hiatal hernia, on the other hand, is associated with structure abnormality of EGJ. Sleeve gastrectomy (SG) has been becoming a standalone bariatric surgery for decades, and it has been proved to effectively induce long-term weight loss in morbidly obese patients. Some studies found morbidly obese patients benefited from resolution of GERD after SG, however, other studies had the opposite findings. Some morbidly obese patients had aggravating GERD or de novo GERD after SG. The mechanism is still unclear now. It might result from removal of fundus and sling muscular fibers of EGJ, increased intra-gastric pressure (IIGP), and hiatal hernia after surgery. High resolution impedance manometry (HRIM) is used to access esophageal and EGJ function objectively. Impedance reflux was more frequently observed in patients having gastroesophageal reflux (GER) symptoms after SG. In addition, previous studies also found decreased EGJ resting pressure, decreased length of lower esophageal sphincter (LES), and presence of hiatal hernia were associated with more GERD after SG. Objective: To evaluate the long-term EGJ function and GERD in morbidly obese patients with hiatal hernia receiving laparoscopic sleeve gastrectomy (LSG) with or without hiatal hernia repair (HHR).

NCT ID: NCT03735862 Completed - Clinical trials for Gastroesophageal Reflux

Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH

Start date: June 1, 2017
Phase:
Study type: Observational

Investigator will identify a consecutive cohort of patients who have undergone a hiatal hernia repair and are at least 6 months post index procedure.

NCT ID: NCT03730233 Completed - Hiatal Hernia Clinical Trials

Hiatal Hernia Repair by Tension-free Mesh Closure or Simple Suturing

Start date: January 11, 2006
Phase: N/A
Study type: Interventional

One-hundred and fifty-nine patients undergoing Nissen fundoplication for symptomatic gastro-oesophageal reflux disease (GORD), who had a concomitant hiatal hernia of > 2 cm axial length, were randomized to closure of the diaphragmatic hiatus with either crural sutures alone or tension-free closure with a non-absorbable mesh. Primary outcome variable was the incidence of radiologically verified recurrent hiatal hernia. Secondary outcomes were per-and postoperative complications and courses, symptomatic recurrence rate, use of PPI, postoperative oesophageal acid exposure and Quality of Life.

NCT ID: NCT03143608 Completed - Clinical trials for Gastro Esophageal Reflux

GERD Treatment With Transoral Incisionless Fundoplication (TIF) Following Hiatal Hernia Surgery

GERD
Start date: May 1, 2014
Phase: N/A
Study type: Observational [Patient Registry]

The investigators prospectively studied ninety nine GERD patients following laparoscopic hiatal surgery combined with transoral incisionless fundoplication at two community hospitals. General surgeons and gastroenterologists participated in the study. GERD questions were recorded before and at six and twelve months.

NCT ID: NCT03058731 Completed - Clinical trials for Paraesophageal Hernia

ACELL Mesh for Paraesophageal Hernia Repair

Start date: February 2, 2016
Phase:
Study type: Observational

This is a prospective, case-matched, systematic follow up of up to 70 pre-existing patients whom underwent paraesophageal hernia repair between June 1, 2012 and September 30, 2016. Patients whom are willing to participate in the study will be asked to return for a one time follow up visit to reassess for hiatal hernia recurrence both symptomatically and radiologically to compare the efficacy of the use of MatriStem Surgical Matrix (ACell) mesh to other biologic meshes.

NCT ID: NCT03025932 Enrolling by invitation - Hiatal Hernia Large Clinical Trials

Recurrence Rate After Laparoscopic Repair of Large Hiatal Hernia

Start date: January 2016
Phase:
Study type: Observational

Patients who underwent laparoscopic repair of large hiatal hernias and anterior fundoplication with mesh are examined for their recurrence rate one year after surgery.

NCT ID: NCT02923362 Active, not recruiting - Clinical trials for Gastroesophageal Reflux Disease

Registry of Outcomes From AntiReflux Surgery

ROARS
Start date: May 2016
Phase:
Study type: Observational [Patient Registry]

Prospective registry comparing outcomes after laparoscopic treatment of gastroesophageal reflux disease and hiatal hernia.