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Clinical Trial Summary

A Study of XMT-2056 in advanced/recurrent solid tumors that express HER2.


Clinical Trial Description

The first-in-human (FIH) study of XMT-2056 is a Phase 1, open-label study of XMT-2056 in previously treated patients with advanced/recurrent solid tumors expressing HER2. The XMT-2056 monotherapy trial will consist of dose escalation (DES) and expansion (EXP) parts. DES will be the dose-finding portion of the study to assess the safety and tolerability of XMT-2056 and determine the maximum tolerated dose (MTD) and/or Recommended Phase 2 Dose (RP2D). The RP2D will be determined based on the totality of the clinical data, including safety and preliminary anti-tumor effect, PK, and relevant biomarker data. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05514717
Study type Interventional
Source Mersana Therapeutics
Contact Janice Kim
Phone 617-715-8214
Email medicalinformation@mersana.com
Status Recruiting
Phase Phase 1
Start date January 24, 2023
Completion date April 2027

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