CT-based Radiomics of ALN pCR (ypN0) in Breast Cancer Undergoing NAC

Status Recruiting

Clinical Trial Summary

This is a prospective, single-center, non-randomized, non-controlled observational study.

Clinical Trial Description

Almost 55-62% of patients with triple-negative or human epidermal growth factor receptor 2 (HER2) positive, node-positive breast cancer achieve an axillary pathologic complete remission (pCR) after neoadjuvant chemotherapy (NAC). To avoid surgery post-NAC, it is paramount to accurately identify patients who achieve pCR in axillary lymph node (ALN). We found that patients with normal-appearing lymph nodes on computed tomography (CT) based radiomics of the axilla after chemotherapy had a lower risk of developing residual nodal disease. However, the features of CT-based radiomics for pCR ALN following NAC has not been established yet. This study aimed to assess the performance of CT-based radiomics in evaluating the response and predicting pCR of metastatic lymph nodes after NAC in breast cancer patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04457700
Study type	Observational
Source	Peking University
Contact	Lize Wang, MD
Phone	+86-10-88271119
Email	lize2010@163.com
Status	Recruiting
Phase
Start date	November 1, 2020
Completion date	December 30, 2022

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