Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy

Hepatocellular Carcinoma Clinical Trial

Official title: Effect of Low Tidal Volume Ventilation Strategy Combined Goal -Directed Fluid Therapy on Intraoperative Bleeding Undergoing Laparoscopic Major Hepatectomy in Liver Cancer Patients: a Surgeon Blinded Randomized Controlled Study

Status Not yet recruiting

Clinical Trial Summary

This randomized controlled study's objective is to find a safer mechanical ventilation strategy to reduce intraoperative bleeding in liver cancer patients undergoing laparoscopic major liver resection. The hypothesis is that low tidal volume ventilation in laparoscopic major hepatectomy results in less bleeding.

Clinical Trial Description

Patients are randomized into the conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group and low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume group and ventilated accordingly throughout the surgery. All patients undergo general anesthesia with propofol, remifentanil, and rocuronium and are intubated with an endotracheal tube (ID 7.0 for females, ID 7.5 for males). Anesthesia is maintained with sevoflurane, end tidal CO2 is targeted between 30-35mmHg. The radial artery is cannulated and connected to the Flotrac sensor and goal directed fluid therapy is done. The estimated blood loss is checked as the primary outcome. In addition postoperative complications, transfusion amounts, operation time, satisfaction of the surgeon and participants are also recorded. ;

Related Conditions & MeSH terms

• Blood Loss, Surgical
• Hepatocellular Carcinoma
• Liver Cirrhosis
• Ventilator Lung

• NCT number: NCT05490147
• Study type: Interventional
• Source: Seoul National University Hospital
• Contact: Seong Mi Yang
• Phone: +82-10-7300-6282
• Email: seongmi.yang@gmail.com
• Status: Not yet recruiting
• Phase: N/A
• Start date: August 8, 2022
• Completion date: August 8, 2023