Effect of Sarcopenia on Hepatocellular Carcinoma(HCC) After Systemic Therapies

Hepatocellular Carcinoma Clinical Trial

Official title: Effect of Sarcopenia on the Efficacy and Prognosis of HCC Treated With Systemic Therapies

Status Enrolling by invitation

Clinical Trial Summary

Sarcopenia is associated with the prognosis of HCC and cholangiocarcinoma. But there has been rare study focusing on the effect of sarcopenia on the prognosis of HCC treated with systemic therapy, such as interventional therapy, targeted therapy, chemotherapy and immunotherapy and so on.

Clinical Trial Description

By tracking the short-term and long-term results of HCC patients treated with systemic therapy,the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after systemic treatments was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.All implementation details are based on the newest EuropeanWorking Group on Sarcopenia in Older People(EWGSOP) definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes, the differences were analyzed and the relationship between sarcopenia and prognosis of systemic treatments was explored. ;

Related Conditions & MeSH terms

• Carcinoma
• Carcinoma, Hepatocellular
• Hepatocellular Carcinoma
• Sarcopenia

• NCT number: NCT05448222
• Study type: Observational
• Source: First Affiliated Hospital of Wenzhou Medical University
• Status: Enrolling by invitation
• Start date: July 1, 2022
• Completion date: December 1, 2024