Prognosis Analysis of Elderly Donor Liver in Liver Transplantation

Hepatocellular Carcinoma Clinical Trial

Official title:

Prognosis Analysis of Elderly Donor Liver From Donation After Cardiac Death in Liver Transplantation: a Multicenter Clinical Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05355662
• Other study ID #: No. XJTU1AF-CRF-2019-029
• Status: Completed
• Start date: January 1, 2015
• Est. completion date: December 31, 2018

Study information

• Verified date: March 2022
• Source: First Affiliated Hospital Xi'an Jiaotong University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Description:

Since the Chinese organ donation system was developed in 2015, donation has been the only source of organs for transplantation in China. Adult patients (age 18 or older) who underwent LT using grafts from deceased donors between January 1st, 2015, and December 31st, 2018, were retrospectively identified using the CLTR, a database and official website for national data gathering. Based on the follow-up data of elderly DCD donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11569
• Est. completion date: December 31, 2018
• Est. primary completion date: December 31, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Recipient age = 18 years and < 65 years.

2. Donor age = 18 years.

Exclusion Criteria:

1. Recipient age <18 years or =65 years.

2. Donor age <18 years.

3. Patients who died within 30 days after transplantation.

4. Secondary liver transplantation.

5. Multiple organ transplantation.

6. Patients with incomplete data or failed follow-up.

Related Conditions & MeSH terms

• Carcinoma, Hepatocellular
• Hepatocellular Carcinoma
• Liver Transplantation
• Survival

Intervention

Other:
• Age
The study was retrospective and did not involve the application of interventions.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
First Affiliated Hospital Xi'an Jiaotong University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Post-operative survival time	Postoperative survival time for patients receiving liver transplantation	Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.
Primary	Transplanted liver status	Postoperative Liver Function in Patients Undergoing Liver Transplantation	Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.The functional status of the transplanted liver was recorded during this period.
Primary	Recurrence of the primary disease after surgery	Recurrence of primary disease in patients who underwent liver transplantation after surgery	The time period between liver transplantation and the initial examination revealing a recurrence of primary disease, or until the end of follow-up on December 31, 2020.whichever came first, assessed up to 72 months.
Secondary	Surgery details	Detailed information such as operation time	Intraoperative
Secondary	Post-operative complications in patients who underwent liver transplantation	Specific details of all post-operative complications in patients who underwent liver transplantation	Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.During this period, all postoperative complications of the patient will be recorded.