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Clinical Trial Summary

The is a phase II, single arm, open-label, multi-site trial studying the combination of cryoablation therapy and dual checkpoint inhibition with nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) given at the recommended phase 2 dose (RP2D) in pediatric and young adult patients with relapsed or refractory solid tumors.


Clinical Trial Description

Patients less than 40 years old with relapsed/refractory solid tumors and at least two sites of measurable disease will receive the current pediatric RP2D of nivolumab and ipilimumab for one cycle and undergo cryoablation therapy of one tumor site. Patients will continue to receive cycles of checkpoint inhibition as long as there is no disease progression of unacceptable toxicity (maximum of 13 cycles [12 months]). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05302921
Study type Interventional
Source Children's National Research Institute
Contact
Status Active, not recruiting
Phase Phase 2
Start date February 18, 2022
Completion date July 1, 2025

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