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Clinical Trial Summary

Open-label, dose escalation, multi-center, Phase I / II study to assess the safety of an autologous T-cell product (ET140203) in adult subjects with Alpha-fetoprotein (AFP)-positive/Human Leukocyte Antigen (HLA) A-2-positive advanced hepatocellular carcinoma (HCC).


Clinical Trial Description

The purpose of this study is to investigate an autologous T-cell therapy for advanced hepatocellular carcinoma (HCC). ET140203 T cells are autologous T cells genetically modified to carry a TCR-mimic (TCRm) construct capable of mediating cell killing by targeting tumor specific intracellular antigens and addressing solid tumor therapy challenges. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04502082
Study type Interventional
Source Eureka Therapeutics Inc.
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date April 14, 2021
Completion date June 20, 2023

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