Study of TG02 Citrate in Patients With Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma Clinical Trial

Official title:

A Phase 1 Dose-Escalation and Pharmacokinetic Study of TG02 Citrate in Patients With Advanced Hepatocellular Carcinoma

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03738111
• Other study ID #: COF-HK-001
• Status: Withdrawn
• Phase: Phase 1
• Start date: December 2018
• Est. completion date: December 2021

Study information

• Verified date: September 2019
• Source: Lee's Pharmaceutical Limited
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a single-centre, open-label, dose escalation, Phase 1 study. The primary objective is to determine the highest dose of TG02 citrate that can safely be given to patients with advanced hepatocellular carcinoma.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 2021
• Est. primary completion date: August 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Adults = 18 years of age at screening;

2. Life expectancy = 3 months;

3. Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1;

4. Subjects must have histologically confirmed locally advanced or metastatic hepatocellular carcinoma (HCC) and have tumor that is refractory to or progressive after sorafenib treatment. Or the subjects are intolerable to sorafenib.

5. Prior local therapy to tumor (e.g. surgery, radiofrequency ablation, percutaneous ethanol injection, chemo-embolization, radiotherapy) is allowed provided that there is a target lesion not subjected to local therapy and/or disease progression has been documented in the target lesion subjected to local therapy. The treatment must be completed at least 4 weeks and patient has recovered from all the acute toxicities of that treatment.

6. At least 28 days, or at least 5 half-lives (whichever is shorter), since last systemic therapy (i.e., chemotherapy, targeted therapy, immunotherapy) before the first dosing of TG02, and have recovered from any clinically significant toxicity associated with such treatment;

7. HCC subjects must be of Child-Pugh class A (not amenable to or refractory to locoregional therapy). Subjects with HCC associated with hepatitis B virus must be receiving adequate antiviral therapy.

8. Must have at least 1 measurable lesion per RECIST 1.1 and evidence of disease progression since the last anti-tumor therapy.

9. Adequate hematologic, renal and hepatic function:

White Blood Cells =2000/uL Neutrophils =1500/uL Platelets =75,000/uL Hemoglobin =9.0g/dL (may have been transfused) Creatinine =2mg/dL Aspartate Aminotransferase (AST) <5 x upper limit of normal (ULN) alanine aminotransferase (ALT) <5 x upper limit of normal (ULN) Bilirubin =2 x ULN (except subjects with Gilbert's syndrome, who must have total bilirubin <3.0mg/dL) INR =1.5

10. Persistent clinically significant toxicities from prior chemotherapy must be = grade 1.

11. Ability to take oral medicine.

12. Negative urine pregnancy test at the time of first dose for women of child bearing potential (WOCBP). For men and WOCBP, adequate contraception must be used throughout the study. For this study, acceptable methods of contraception include a reliable intrauterine device or a spermicide in combination with a barrier method. Hormonal forms of birth control (oral, implantable, or injectable) may only be used if combined with a barrier method.

13. Ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and return for the required assessments.

Exclusion Criteria:

1. Past liver transplantation.

2. Uncontrollable hepatic encephalopathy or ascites.

3. Congestive heart failure (New York Heart Association Class III to IV), symptomatic ischemia, conduction abnormalities uncontrolled by conventional intervention, and myocardial infarction within 6 months prior to first dose.

4. Screening ECG with a prolonged QTc interval (males: >450ms; females: >470ms) as calculated by the Fridericia correction formula despite balancing of electrolytes and/or discontinuing any drugs known to prolong QTc interval.

5. Concurrent severe or uncontrolled medical disease (e.g., active systemic infection, diabetes, hypertension, coronary artery disease) that, in the opinion of the investigator, would compromise the safety of the patient or compromise the ability of the patient to complete the study.

6. Symptomatic CNS or brain metastases.

7. Psychiatric illness/social situations that would limit compliance with study requirements.

8. Prior or second malignancy, except non-melanoma skin cancer, completed resected cervical or prostate cancer (with prostate-specific antigen (PSA) of less than or equal to 0.1ng/ml), or other cancer for which the subjects has received curative therapy at least 3 years prior to study entry.

9. Patient with pleural effusions requiring thoracentesis or ascites requiring paracentesis.

10. Acute hepatitis.

11. The subject is receiving an investigational drug, has an investigational device in place or has participated in an investigational drug or device study within 30 days prior to screening.

12. Pregnant or nursing.

13. History of drug abuse and taking drugs (such as marijuana, cocaine, opiates, benzodiazepines, amphetamines, barbiturates).

14. History of addicted to alcohol within 6 months before the study which defines as an average weekly intake of greater than 14 units (one unit=17.7ml ethanol, which is equivalent to 357ml beer with 5% alcohol content or 44ml spirits with 40% alcohol content or 147ml wine with 12% alcohol content).

15. Subjects who, in the opinion of the investigators, should not participate in the study.

Related Conditions & MeSH terms

• Carcinoma
• Carcinoma, Hepatocellular
• Hepatocellular Carcinoma

Intervention

Drug:
• TG02 Citrate
TG02 citrate capsules

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Lee's Pharmaceutical Limited	China Oncology Focus Limited

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Molecular Marker	Correlation of molecular marker, c-MYC, with measures of clinical benefit.	At baseline
Primary	Maximum Tolerated Dose	To assess the number of patients with dose-limiting toxicities (DLT) and the dose of TG02 citrate that can be safely given to patients with advanced hepatocellular carcinoma.	28 days
Secondary	Adverse Event	All adverse events will be graded according to NCI-CTCAE, Version 4	up to 12 months
Secondary	Objective Response Rate, with respect to RECIST version 1.1	Proportion of patients, whose best overall response is either Complete Response or Partial Response, confirmed at least 4 weeks after initial documentation.	Up to 12 months
Secondary	Progression Free Survival		At progression, up to 12 months
Secondary	Overall Survival		At death, up to 12 months