Hepatocellular Carcinoma Clinical Trial
Official title:
Hepatocellular Carcinoma in Patients With a Cirrhosis Due to an Alcoholic or a Non Alcoholic Fatty Liver Disease
Global prevalence of Non Alcoholic Fatty Liver Diseases (NAFLD) ranges from 22% to 28%.The
spectrum of these hepatic abnormalities extends from isolated steatosis to steatohepatitis
(Non Alcoholic Steato-Hepatitis, NASH) and steatofibrosis leading to cirrhosis and
hepatocellular carcinoma. NAFLD is one of the main causes of cirrhosis and increases the risk
of liver-related death and hepatocellular carcinoma (developed in patients with or without
cirrhosis). Despite this major public health concern, apart from lifestyle changes, treatment
of NAFLD is still elusive as there is lack of efficacious pharmacological treatment.
Alcoholic liver diseases are also frequent in Western countries. Alcoholic liver diseases and
NAFLD share common pathological lesions and molecular pathways. This is illustrated by the
emerging role of abnormalities of the microbiota (dysbiosis) in these 2 diseases leading to
the concept of " liver-gut axis ". Whereas the molecular mechanisms responsible for the
progression from a "safety" state to NASH or to a severe alcoholic steato-hepatitis are still
unclear, hepatic inflammation is a key factor involved in the progression of NAFLD and
alcoholic liver disease.
The hypothesis is that cellular and molecular abnormalities and gut dysbiosis could be
present in patients with simple steatosis or with steato-hepatitis and could be responsible
for the occurrence of hepatocellular carcinoma particularly without cirrhosis.
The main objective is to compare cellular and inflammatory pathways in liver with and without
hepatocellular carcinoma in patients with alcoholic or non-alcoholic fatty liver diseases.
n/a
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