Hepatocellular Carcinoma Clinical Trial
Official title:
Pilot Study to Evaluate the Signaling Pathway Modulation Demonstrated by Raf, MEK, and Kinase Inhibitors In Human Skin With or Without Solar Simulated Light
This is a pilot study designed to evaluate the cutaneous effect of systemic inhibition of the
tyrosine kinase pathway in the presence or absence of solar simulated light exposure.
A maximum of 45 subjects will be accrued into the overall study we anticipate approximately
25 patients in the Raf inhibitor group and 10 patients each into the Tyrosine Kinase and MEK
inhibitor arms of the study.
The study will evaluate the modulatory effect of systemic Raf inhibition in the MEK/ERK and
PI3 /Akt/mTOR pathways in patients undergoing targeted therapy for metastatic disease.
Changes in relevant proteins will be evaluated using a combined protein expression
methodology that in includes immunohistochemistry (IHC) and reverse phase protein microarray
(RPPA) technology.
The primary endpoint of this study will be assessed in normal skin and skin acutely exposed
to solar simulated light
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