Hepatocellular Carcinoma Clinical Trial
Official title:
Phase I Trial of Anti-GPC3 Chimeric T Cells for Subjects With GPC3-Positive Advanced Hepatocellular Carcinoma
The goal of this clinical trial is to evaluate the safety and efficacy of anti-GPC3 scFv-41BB-CD3ΞΆ-tEGFR chimeric antigen receptor (CAR)-modified T (CAR-T) cells in treating patients with GPC3-positive advanced hepatocellular carcinoma (HCC).
Primary Objectives:
1. To evaluate the safety of intravenous administration of the anti-GPC3 CAR-T cells in
patients with HCC or lung squamous cell carcinoma
2. To access the safety of anti-GPC3 CAR-T cells in HCC patients through catheter
injection
Secondary Objectives:
1. To evaluate the efficacy of anti-GPC3 CAR-T cells in patients with advanced HCC or lung
squamous cell carcinoma
2. To monitor the serum cytokine and expression level of tumor markers such as AFP, CEA
and GPC3
3. To assess the persistence in peripheral blood and intratumoral infiltration of
anti-GPC3 CAR-T cells
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