Hepatocellular Carcinoma Clinical Trial
Official title:
Impact of Interferon Free Regimens in Patients With Chronic HCV and Successfully Treated HCC
The study will recruit 150 patients with HCV related HCC ,after HCC treatment the patients will undergo treatment with different regimens of DAAs.
The study will recruit 150 patients with HCV related HCC All the studied patients underwent
or will undergo one of the curative interventions for HCC either hepatic resection or
thermal ablation .
after 1 month of achievement of laboratory and radiological response to HCC intervention the
patient will be treated with one of the interferon free regimens :
1. Sofosbuvir+Ribavirin
2. Sofosbuvir+Simeprevir± Ribavirin
3. Sofosbuvir+ Daclatasvir ± Ribavirin
4. Sofosbuvir+ Ledipasvir ± Ribavirin
the treatment duration will be justified either 12 or 24 weeks after treatment the patient
will continue on regular follow up to detect HCV cure or recurrence , HCC cure or recurrence
and long term follow up of natural history
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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