Hepatocellular Carcinoma Clinical Trial
Official title:
The Effect of Postoperative Interferon-alpha Treatment in Patients Underwent Curative Surgery for Hepatocellular Carcinoma With a Low miR-26 Expression: a Multi-center Randomized Clinical Trial.
The purpose of the study is to determine whether interferon-alpha is effective in prevention of tumor recurrence for the patients with a low miR-26 expression in tumor after curative resection of hepatocellular carcinoma.
BACKGROUND: Postoperative interferon-alpha (IFN-alpha) therapy improved survival in patients
with hepatocellular carcinoma (HCC). MiR-26 is a predictive marker for the effect of
postoperative interferon-alpha treatment in patients with HCC. Our study is to identify the
effect of postoperative IFN-alpha treatment in patients with a low miR-26 expression in tumor
after resection of HCC.
METHODS: A quantitative RT-PCR assays of miR-26 are performed on specimens which are
collected from patients who underwent a curative resection of HCC. These patients with low
miR-26 expression will return to the hospital 4 to 6 weeks after the resection following the
baseline examination to rule out residual tumor. If all requirements are satisfied, these
patients will be randomly assigned to the treatment group who received postoperative
IFN-alpha therapy or the control group who will not receive any anti-cancer treatment.
Disease-free survival, overall survival, time to recurrence and the side effects will be
observed.
Anticipated RESULTS: IFN-alpha treatment improved the disease-free survival in patients with
a low miR-26 expression in tumor after curative resection of HCC, probably by inhibiting
tumor recurrence.
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