Hepatocellular Carcinoma Clinical Trial
Official title:
A Phase I Study of STA-9090 in Patients With Advanced Hepatocellular Carcinoma
STA-9090 works by inhibiting the function of a protein in tumor cells called Hsp90. Hsp90 is
thought to play a role in tumor growth. By interfering with this protein's function, STA-9090
may help kill tumor cells. This drug has been used in other research studies and information
from those studies suggests that this agent may help to slow tumor growth in HCC.
The purpose of this research study is to find the highest dose of STA-9090 that can safely be
given to participants with advanced HCC. The investigators will also get more information
about the safety of STA-9090 and perform tests to learn more about how STA-9090 affects the
body.
Study treatment is given in 4-week time periods called cycles. Patients will receive ST-9090
once weekly for the first 3 weeks of each cycle and no treatment on the fourth week. STA-9090
will be given by intravenous (IV) infusion. IV infusions occur through an IV catheter (or
tube) placed in the vein. Each infusion will last about 60 minutes.
During each cycles patients will have blood tests, pregnancy test, and EKG. Twenty to thirty
days after the last dose, patients will return for a physical exam, blood tests, urine test,
EKG, and CT or MRI of chest and abdomen.
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