Hepatocellular Carcinoma Clinical Trial
Official title:
Phase I/II Study of SIR-Spheres Plus Sorafenib as First Line Treatment in Patients With Non-Resectable Primary Hepatocellular Carcinoma
This Phase I/II trial will evaluate the safety and activity of chemo-radiotherapy comprising
a regimen of Sorafenib chemotherapy plus SIR-Spheres yttrium-90 microspheres
(chemo-radiotherapy, also known as "chemo-SIRT"), for first-line treatment of patients with
primary hepatocellular carcinoma (HCC) in whom surgical resection is not feasible.
This study is designed as a prelude to a planned future randomised comparative study that
will compare the efficacy of Sorafenib plus SIR-Spheres versus Sorafenib alone, in this
patient population.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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