A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol (S-HCC)

Status Recruiting

Clinical Trial Summary

Patients with hepatocellular carcinoma and esophageal varices bleeding were randomized to undergo endoscopic ligation alone (group A) and additive propranolol treatment (group B) after stabilization of their first acute bleeding.

Clinical Trial Description

Esophageal variceal bleeding is characteristic of high rebleeding rate and mortality. Thanks to the recent advance of treatment for variceal bleeding such as non-selective beta blocker (NSBB) added to endoscopic ligation further reduce rebleeding in cirrhotic patients, the rebleeding rate and mortality has a marked reduction. However, hepatocellular carcinoma (HCC) is a distinct group characteristic of very poor prognosis in patients with portal hypertension when compared to those of liver cirrhosis only. Therefore, the investigators design a study to randomize patients with HCC and acute variceal bleeding to endoscopic treatment alone and combination with endoscopic treatment and NSBB. This is the two years study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01451658
Study type	Interventional
Source	Taipei Veterans General Hospital, Taiwan
Contact
Status	Recruiting
Phase	Phase 4
Start date	December 2009
Completion date	December 31, 2020

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