Hepatitis C Clinical Trial
Official title:
The Effect of Aerobic Exercise on Liver Enzymes in Overweight Prediabetic Patients With Hepatitis c
Exercise is one of the most vital components of health maintenance. Exercising regularly
maintains the cardiovascular system health, promotes the health of liver, and declines the
risks of complications induced by CHCV. Since overweight is the main risk factor for IR and
type 2 DM which may speed the liver disease progression among HCV patients, exercise is very
important for maintenance and loss of weight. Further, exercise can relieve the side effects
of medications of HCV, improve immunity, promote a sense of well-being, reduce levels of
chronic fatigue, improve blood oxygen levels and increase the endorphins excretion which
makes the patients fully energized (Elgendi, Shebl A, Sliem M, and Gary FA, 2018).
Studies on exercise effect in patients with CHCV are quite scarce (de Sousa Fernandes et al.,
2019). Decreased leptin levels by exercise positively modulate insulin signaling and inhibit
pathology progression (Anaruma et al., 2019). Since studies investigated physical activity
effect on regulating HCV related leptin levels are very little, the present study aimed to
explore the response of serum leptin and liver enzymes to aerobic exercise in nondiabetic
overweight men with CHCV.
The study group (n=20) received three sessions of aerobic walking exercise per week for 3 months. Every session was done on an electronic treadmill with no inclination started with 5 minutes warm-up then 30 minutes of moderate-intensity aerobic training with 60-75% of target heart rate then followed or ended by 5 minutes cool down. The control group (n=20) will receive no training. ;
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