Hepatitis B, Chronic Clinical Trial
Official title:
A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Tolerability, Pharmacokinetics of AHB-137 With Single Ascending Doses and Multiple Ascending Doses in Healthy Volunteers and Initial Efficacy With Multiple Ascending Doses in Chronic Hepatitis B Patients
The purpose of this study is to evaluate the tolerability, and pharmacokinetics of AHB-137 subcutaneous injection in healthy participants after single and multiple doses. In addition, the study will evaluate the antiviral efficacy of AHB-137 in chronic hepatitis B (CHB) patients following a multiple dosing regimen.
This study is a two-part study of AHB-137, including Part Ia and Part Ib. Part Ia evaluates the tolerability, pharmacokinetics of AHB-137 following subcutaneous single-ascending doses (SAD) or multiple-ascending doses (MAD) in healthy volunteers. Part Ib is a multiple dose study to assess the safety, tolerability, pharmacokinetics, and antiviral efficacy of AHB-137 in chronic hepatitis B (CHB) patients. ;
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