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NCT02814240 Clinical Trial

Hepatic Steatosis and Pituitary Gland Failure, Evaluation by Nuclear Magnetic Resonance (NMR) Imaging

Hepatic Steatosis Clinical Trial

— SHAH  

Official title:
Hepatic Steatosis and Pituitary Gland Failure, Evaluation by NMR Imaging

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02814240
Other study ID # PETIT NOVARTIS 2014
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 16, 2015
Est. completion date October 10, 2015

Study information
Verified date February 2024
Source Centre Hospitalier Universitaire Dijon
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigator put forward the hypothesis that liver fat mass in patients with pituitary gland failure is greater than that in a control population. Failure of the anterior pituitary and more particularly impaired production of growth hormone (GH) could be the principal mechanism responsible for increased liver fat mass in these patients.

Recruitment information / eligibility
Status Completed
Enrollment 21
Est. completion date October 10, 2015
Est. primary completion date October 10, 2015
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patients who have provided consent - Patients over 18 years - Patients with pituitary disease (Pituitary adenoma, anterior pituitary failure, craniopharyngioma, empty sella syndrome, hypophysitis, infiltration of the stalk) requiring Magnetic Resonance Imaging (MRI) of the pituitary. Exclusion Criteria: - Persons without national health insurance - Pacemaker (Contra-Indication for MRI) - Alcohol consumption greater than 4 glasses a day - Any treatment able to increase liver fat content (glitazones, systemic corticoids, immunosuppressants) are forbidden - Presence of metallic implants (Contra-Indication for MRI) - Claustrophobia - Adult under guardianship - Pregnant or breast-feeding women - Patients with a liver disease other than non-alcoholic steatosis

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• NMR

Biological:
• Blood samples

Other:
• fibroscan

Locations
Country Name City State
France CHU Dijon Bourgogne Dijon

Sponsors (1)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire Dijon

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Measurement of liver fat mass by Magnetic Resonance Imaging (MRI) Measured at Day 0
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