Hemolytic Uremic Syndrome Clinical Trial
Official title:
Repetitive Intestinal Lavage Using Polyethylene Glycol Solution in Patients With EHEC O104:H4 Infection During the German 2011 Outbreak for Prevention of Severe Thrombocytopenia With Subsequently Following Therapeutic Plasmapheresis
The investigators examined the outcome of patients with severe Enterohaemorrhagic E. Coli (EHEC) O104:H4 infection suffering from bloody diarrhoea that were at risk to develop hemolytic uremic syndrome and underwent repetitive whole bowl lavage during hospitalization.
During the 2011 German EHEC O104:H4 outbreak, centered in the area of Hamburg, 33 patients
with EHEC associated hemorrhagic colitis were admitted to the first Department of Medicine
of the Hamburg University medical centre.
The first 12 patients were treated symptomatically and received intravenous rehydration up
to three liters daily.
Prompted by a good clinical response after whole bowel irrigation with polyethylene
glycol-solution (PEG)in patient 13 all subsequent admitted patients (n=21) were treated with
PEG-solution ( 2 liters on admission followed by one liter per day during the clinical
course).
During the hospital course blood work was obtained every day and patients were examined for
clinical symptoms.
Thrombocytopenia below 100.000/microliter was defined as a threshold for initiating
therapeutic plasmapheresis to prevent the onset of hemolytic syndrome on an early stage.
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Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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