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Hemoglobin S Disease clinical trials

View clinical trials related to Hemoglobin S Disease.

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NCT ID: NCT02571088 Completed - Clinical trials for Hemoglobin S Disease

Evaluation of a Training Program for Homozygous Sickle Cell Disease Patients

EXDRE
Start date: September 2014
Phase: N/A
Study type: Interventional

Sickle cell disease (SCD) is the most frequent inherited disease in the world. Literature reports that SCD patients display intolerance to exercise, important muscle weakness and profound remodeling of skeletal muscle including amyotrophy and rarefied microvascular network. Because strenuous exercise induces acidosis, hemorheological alterations, endothelial activation and oxidative stress, it constitutes a potential triggering factor of sickling and vaso-occlusive crisis. As a consequence, physical activity is usually discouraged in patients with SCD. However, moderate and regular physical activity seems to be not only safe but also beneficial for SCD patients.

NCT ID: NCT01322269 Completed - Sickle Cell Disease Clinical Trials

A Study of HQK-1001 in Patients With Sickle Cell Disease

Start date: April 2011
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability of three dose levels of HQK-1001 administered once daily for 26 weeks in subjects with sickle cell disease.