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Clinical Trial Summary

The overarching goal of this study is to determine the role of chronic kidney disease and the activation of the kallikrein-kinin system during hemodialysis on the development of mitochondrial dysfunction; the investigators will measure mitochondrial function using the gold standard method, 31-phosphorus magnetic resonance spectroscopy.

The investigators will test the hypothesis that endogenous bradykinin promotes mitochondrial dysfunction in patients undergoing hemodialysis. The investigators will first perform a randomized, placebo-controlled, double-blind, cross-over study measuring the effect of Icatibant (HOE-140), a bradykinin B2 receptor blocker, on mitochondrial function.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03177798
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase Phase 2
Start date August 1, 2017
Completion date December 31, 2018

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